For me, artwork is an intrinsic part of any interior scheme.
It sets the scene and can give impact to an otherwise dull space. Scale is as important as content. Get it wrong and a piece will lose all of its grandeur and impact becoming lost in an expansive surrounding space.
For this reason, I tend to have bespoke artwork made for each project, prints are scaled to the space and canvas paintings are commissioned to suit the colours and layout of the scheme.